Parathyroidectomy has better outcomes in treating osteoporosis than Fosamax or simple observation


A recent observational study published in Annals of Internal Medicine has demonstrated that parathyoidectomy is more effective in improving osteoporosis in patients with primary hyperparathyroidism than either medical treatment with Fosamax or just long term observation. It examined outcomes in over 6000 patients with hyperparathyroidism followed for fracture. The absolute risk for hip fracture at 10 years was over 20 events per 1000 patients for parathyroidectomy  compared to over 85 events per 1000 patients with Fosamax and over 55 events per 1000 patients with just observation. Similar changes were seen in relation to the risk of any fracture at 10 years. This study clearly raises significant questions about the value of a continued conservative approach to hyperparathyroidism associated osteoporosis when an effective therapy in the form of minimally invasive parathyoidectomy is readily available.


Professor Yeh is  one of America's leading parathyroid  surgeons and undertook his fellowship training in Australia with Professor Delbridge at the University of Sydney Endocrine Surgical Unit. He is now on staff at the Unversity of California, Los Angeles (UCLA) and  has published widely on the role of minimally invasive parathyroid surgery